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Contraindicated (1)phenobarbital will reduce the level or outcome of naloxegol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Use of naloxegol with strong CYP3A4 inducers is not encouragedDoxycycline. Phenobarbital has been shown to shorten the 50 percent-lifetime of doxycycline for as long as two weeks soon after barbit